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Ritonavir or lopinavir/ritonavir significantly enhance plasma concentrations of oxycodone in nutritious human volunteers as a result of inhibition of CYP3A4 and CYP2D6.[58] Rifampicin drastically decreases plasma concentrations of oxycodone as a consequence of sturdy induction of CYP3A4.A crucial A part of the evaluation of a affected individual wi